EXPERIMENTALLY VALIDATED OXIDATIVE STRESS -ASSOCIATED PROGNOSTIC SIGNATURES DESCRIBE THE IMMUNE LANDSCAPE AND PREDICT THE DRUG RESPONSE AND PROGNOSIS OF SKCM

BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities.This study aims to identify novel biomarkers for chemotherapy and Connector Tubing immunotherapy response in SKCM and explore their association with oxidative stress.MethodsUtilizi

The efficacy of lithium for treating the acute symptoms of mania, as well its use as a mood stabiliser is well established.However, lithium has Pickle a narrow therapeutic index and there is potential for fatal toxicity, as well as serious side effects including renal failure.Patient education is important, and psychiatrists need to spend time with

This paper presents a robust hybrid improved dolphin echolocation and ant colony optimization algorithm (IDEACO) for optimizing the truss structures with discrete sizing variables.The dolphin echolocation (DE) is inspired by the navigation and hunting behavior of dolphins.An improved version of dolphin echolocation (IDE), as the main engine, is pro

Residual stresses are usually associated with stresses induced by heterogeneous deformations as a cause of phase transition and thermal stress.The residual stresses can appear during the manufacturing process, repair process, or in some cases due to operational loads.These stresses should be taken into account in the structural integrity evaluation